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------=_NextPart_01C2F7B6.AE018940 Content-Location: file:///C:/ED74248E/Expose-Stefan_fichiers/master21.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C2F7B6.AE018940 Content-Location: file:///C:/ED74248E/Expose-Stefan_fichiers/master02.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
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‹#› ------=_NextPart_01C2F7B6.AE018940 Content-Location: file:///C:/ED74248E/Expose-Stefan_fichiers/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C2F7B6.AE018940 Content-Location: file:///C:/ED74248E/Expose-Stefan_fichiers/slide0003.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Prédiction de la structure secondaire des ARN
DCFold, un algorithme pour la prédiction de structures secondaires d’ARN
Stéfan Engelen<= /span>
Encadrante: Fariza Tahi
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Travaux en cours
<= span style=3D'font-size:75%'>•Probl&egrav= e;me crucial dans l’approche comparative.
•Nombre de séquences tests défini en fonction de la taille n de = = la séquence cible (n/200  si n>800, 4 sinon). •Déve= loppement d’une procédure pour le choix des séquences = tests.
Choix des séquences t= ests
Alignement des séquen= ces
<= span style=3D'font-size:75%'>•Séqu= ences pré-alignées ou alignées par ClustalW.
•Déca= lages autorisés des palindromes dans les séquences <= span style=3D'position:absolute;top:75.0%;left:8.23%;width:90.82%;height:5.5%'>= tests        = ;        insuffisant. •Développement d’une procédure = de réajustement de l’alignement en fonction des palindromes trouvés.
------=_NextPart_01C2F7B6.AE018940 Content-Location: file:///C:/ED74248E/Expose-Stefan_fichiers/slide0043_image009.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhOgAMAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAgA4 AAkAgAAAAP///wImhI+pyxkfmpxUwsuu3rz7/zjgSJaQYabqyrYa6sZbRdciZuf2ORUAOx== ------=_NextPart_01C2F7B6.AE018940 Content-Location: file:///C:/ED74248E/Expose-Stefan_fichiers/slide0018.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Prédiction de la structure secondaire des ARN
Travaux en cours
Traitement des zones forteme= nt variables/conservées <= /span>
<= span style=3D'font-size:75%'>•Utilisation= de nouveaux critères de sélection des palindromes. <= /span>
<= span style=3D'font-size:75%'>•Inté= gration de l’approche thermodynamique.
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Choix des séquences tests
R= 26; Pour vérifier la conservati= on des hélices, DCFold nécessite un bon alig= nement des hélices
• =
• Or, on observe que :
Ø les hélices ne sont pas correctement alignées car elles sont sou= vent assez variables (présentent un grand nombre de mutations= )
Ø l’alignement des héli= ces est souvent décalé de quelques bases
Ø
R= 26; On trouve des séquences tes= ts pour lesquelles l’alignement des hélices est « correc= te »
Il faut trouver un= moyen de différencier les séquences t= ests bien alignées au niveau des hélices de = celles qui ne le sont pas.
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Choix des séquences tests
   
Profils de mutation des séquences tests
•Dans une hélice, les mutations conservées par l’évolution sont celles qui permettent de maintenir l’appariement. •A l’extérieur des hé= lices, toutes les mutations sont conservées = par l’évolution.
Le profil de mutat= ion dans les hélices est différent de celui qui <= span lang=3DFR style=3D'font-family:Tahoma;text-shadow:auto;color:red'>est &agr= ave; l’extérieur (aléatoire?).
A 26.08 = 18.47 38.04 16.3
C 6.0 <= /span>66.5 11.5 15.5
G 10.15= 11.71 66.4 10.15
U 17.56= 31.08 16.89 33.78
A 53.42 = 10.27 12.32 9.93
C 11.87 = 51.87 8.75 8.75
G 9.86 = 8.55 56.57 8.55
U 10.81= 12.16 8.1 56.75 <= /div>
Dans les hélices<= /div>
Extérieur des hél= ices
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Choix des séquences tests
• Si = deux séquences sont correctement alignées et que leurs structures sont très proches (les mêmes hélices) alors on a = une alternance ent= re:
<= span style=3D'font-family:Tahoma;text-shadow:auto'>ü Régions possédant un profil de mutation d’hélices.
<= span style=3D'font-family:Tahoma;text-shadow:auto'>ü Régions ayant un profil d’extérieur d’hélices.
<= span style=3D'font-family:Tahoma;text-shadow:auto;visibility:hidden'>ü
<= span style=3D'font-family:Tahoma;text-shadow:auto;visibility:hidden'>ü
• Si = deux séquences sont mal alignées, il n’y a pas cette alternance.=
Le profil de mutation de = la séquence entière subit l’influence du prof= il de mutation dans les hélices
Le profil de mutation de = la séquence entière ne subit pas l’influen= ce du profil de mutation dans les hélices.
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• Considérons une héli= ce de la séquence cible. Deux cas se présentent si l’alignement est mauvais :
•
ü Soit l’hélice n’= ;est pas conservée et dans ce cas, le profil de mutation est le même que si on était à l’exté= ;rieur d’une hélice.
<= span style=3D'font-family:Tahoma;font-size:58%;text-shadow:auto;visibility:hidd= en'>ü&= #13;
ü Soit l’hélice est conservée mais décalée et dans ce cas, le profil de = mutation est biaisé différemment de celui que l’on observe= dans des hélices correctement alignées.
Choix des séquences tests
Il faut mettre en évidence «un biais» dû aux hélices &agr= ave; utiliser pour choisir les séquences tests.
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cible AGCCC= UUGGAAACCUCG= AAAGGACGGG<= /span>C= UUUUCAGU= UUCUAAGU----AAGCG<= /b>
t1 A<= /b>ACCCAUGAA= AACCCCGAAAGGUUGGGC= UUUUAAGUUUUUA<= b>UG= U----AAGCG<= /b>
t2 A<= /b>ACCCUUGAAA<= b>GCCUCG= AAAGGAUGGCCUUUUCAG<= b>CU= U<= b>UU= AAGU----AAGCG<= /b>
t3 AG= ACCAUCAAGGCGCCGGGAGGACGGGC= U<= b>CCU= CAGU= UUCUAAGU----AAGCG<= /b>
t4 AG= CCC= UUGGAAACCUCG= A<= b>GUG= GACGGG<= /span>C= <= b>AU= UUCAGU= UUCUAAGU----AAGCG<= /b>
t5 AG= CCC= UUGGAAACCUCG= AAA<= b>AGACGGG<= /span><= b>UU= UUUAAGUUUCUAAGU----AAGCG
t6 AG= CCC= UUGGAAACC-----AG= GAAGGG-UUGGC--UUUCUAAGUUUCUAAGUG
H1
H1’
H2
H2’
Choix des séquences tests
<= span style=3D'font-family:Tahoma;text-shadow:auto'>R= 26; Soit un alignement de séque= nces possédant deux hélices:
<= span style=3D'font-family:Tahoma;font-size:83%;text-shadow:auto;visibility:hidd= en'>•
<= span style=3D'font-family:Tahoma;font-size:83%;text-shadow:auto;visibility:hidd= en'>•
<= span style=3D'font-family:Tahoma;font-size:83%;text-shadow:auto;visibility:hidd= en'>•
<= span style=3D'font-family:Tahoma;font-size:83%;text-shadow:auto;visibility:hidd= en'>•
<= span style=3D'font-family:Tahoma;font-size:83%;text-shadow:auto;visibility:hidd= en'>•
ü Les séquences t1, t2, t4 et = t5 sont correctement alignées, elles possède= nt plus de mutations ayant des contraintes d’appariement = (jau= nes) que de mutations sans contrainte (verte). Le profil de ces s&ea= cute;quences est donc biaisé vers un profil de mutation d ’hélices.
ü La séquence t3 qui ne possède pas l’hélice H1 et la séquence t6 dont l ’alignement est décalé ont plus de mutations sa= ns contrainte. Le profil de ces deux séquences est mo= ins biaisé vers le profil d ’hélice.
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Choix des séquences tests
Résultats
<= span style=3D'font-family:Tahoma;text-shadow:auto'>R= 26; Dans les hélices on observe plus souve= nt les mutations:
ü A -= -> G et U --> C dans les mêmes proportions
ü G -= -> A et C --> U dans les mêmes proportions
par rapport aux au= tres mutations possibles.
Ceci a deux causes= :
ü L’existence d’un intermédiaire stable G-U pour ces deux doubles mutations <= /span>
ü La plus grande facilité &ag= rave; faire des transitions plutôt que des transversions=
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• Le = biais dû aux hélices se répercute effectivement dans = = les profils de mut= ation des séquences entières
Choix des séquences tests
Résultats
En p= osant des critères sur les profils de mutation des séquences on pourra à choisir les séquences tests intéressantes pour la prédiction de structure secondaire.
A C<= span style=3D'mso-tab-count:1;width:18.18%'> G U
A 48= .4 9.68 13.34<= /span> 11.7= 6
C 9.= 04 47.98 10.49 <= /span>17.58
G 14= .88 9.38 49.12 = 12.19
U 13= .96 14.07 11.4 <= /span>45.85
A C<= span style=3D'mso-tab-count:1;width:18.18%'> G U
A 46= .87 12.23 18.48<= /span> 11.4= 5
C 8.= 61 60.0 10.27 = 12.5
G 10= .04 10.53 62.74 <= /span>9.55
U 14= .18 21.62 12.5 <= /span>45.27
A C<= span style=3D'mso-tab-count:1;width:18.18%'> G U
A 26= .08 18.47 38.04<= /span> 16.3=
C 6.= 0 66.5 11.5 = 15.5
G 10= .15 11.71 66.4 <= /span>10.15
U 17= .56 31.08 16.89 <= /span>33.78
Toutes les séquences = entières
Les séquences intéressantes entières
Les palindromes des séquences intéressant= es
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Choix des séquences tests
Alternative au choix des séquences tests:=
cible AG= CCCUUG= GAAACCUCGAAA= GGACGGG<= span lang=3DFR style=3D'font-family:"Courier New";font-size:75%;color:red'>CUUU= UCAGUUUC= UAAGU----AAGCG
t1 AACCCAUGAAAACCCCGAAAGGUUGGGCUUU= UAAGUUUUUAUGU----AAGCG
t2 AACCCUUGAAAGCCUCGAAAGGAUGGCCUUUUCAGUUUUAAGU----AAGCG
t3 AGACCAUCAAGGCGCCGG= GAGGACGGG<= span lang=3DFR style=3D'font-family:"Courier New";font-size:75%;color:red'>CUC= CUCAGUUUC= UAAGU----AAGCG
t4 AGCC<= /span>CUUG= GAAACCUCGAG= UGGACGGG<= span lang=3DFR style=3D'font-family:"Courier New";font-size:75%;color:red'>CA= UUU<= /span>CAGUUUC= UAAGU----AAGCG
t5 AGCC<= /span>CUUG= GAAACCUCGAAA= A= GACGGG<= span lang=3DFR style=3D'font-family:"Courier New";font-size:75%;color:yellow'>U= UUUU= AAGUUUCUAAGU----AAGCG
t6 AGCC<= /span>CUUG= GAAACC-----AGGA<= /span>AGGG-UUGGC--UUUC= UAAGUUUCUAAGUG
H1
H1’
H2
H2’
Considérons de nouveau cet alignement:
S= i pour prédire la structure on doit choisir 5 séquences tests, on <= /span>n’arrivera pas = à trouver les deux hélices.
Une solution peut être de choisir un jeu= de séquences différent pour chaque hélice. Dans ce cas on choisit de t1,t= 2,t4,t5,t6 pour H1 et t1,t2,t3,t4,t5 pour H2.
 
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= Alignement des séquences
•Recherche des palindromes da= ns la séquence cible
Séquence cible
•Vérification de leur conservation dans les séquences tests:
&uum= l;Ouverture d’une fenêtre plus grande:&#= 13;
ü
ü
ü
ü
&uum= l;Alignement local des deux mots du palindrome avec = les règles dR= 17;appariement des nucléotides et attribution de scores aux séquences tests
•Alignement des zônes ouvertes en forç= ant l’alignement au niveau= des hélices
Séquence cible
Séquences tests
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= = Traitement des zones fortement variables/conservées<= /span>
= ;
   
̶= 6; Appliquer la reflexion sur les pro= fils à de petites régions et éliminer ainsi les séquences= trop éloignées
̶= 6; Permettre de choisir des séquences tests différentes = suivant les hélices que l= 217;on considère
R= 26; Intégrer l’approche thermodynamique à ces petites régions
• Utiliser de nouveaux critèr= es de sélections:
Zones variables: Empécher l’appariement de ces régions avec des régions éloignées car elles correspondent souvent à des boucles terminales ?<= /span>
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= Application de l’algorithme
• Vali= dation sur d’autres structures connues (Ex : les introns de <= span style=3D'position:absolute;top:22.5%;left:3.74%;width:95.5%;height:5.5%'><= span style=3D'font-size:75%'>groupe I, l’operon alpha-mRNA). =
•
• Prédiction de structures non encore connues.
•
• Prédiction de motifs (“hammerhead,hairpin” …)
•
• Application pour la recherche de gènes.
•
• DCFo= ld est un outil informatique pour cibler et faciliter = l’analyse des résultats des mé= thodes biologiques (RMN, cristall= ographie)
•
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&= #8249;en-tête› <= /span>
‹date/heure› <= /span>
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= 1000 ); else document.body.start(); } } function MakeSldVis() { var fTrans=3Dg_showAnimation && SldHasTrans() if( fTrans ) { if( g_bgSound ) { idx=3Dg_bgSound.indexOf(","); pptSound.src=3Dg_bgSound.substr( 0, idx ); pptSound.loop=3D -(parseInt(g_bgSound.substr(idx+1))); } SlideObj.filters.revealtrans.Apply() } SlideObj.style.visibility=3D"visible" if( fTrans ) SlideObj.filters.revealtrans.Play() } function MakeNotesVis() { if( !IsNts() ) return false SlideObj.style.display=3D"none" nObj =3D document.all.item("NotesObj") parent.SetHasNts(0) if( nObj ) { nObj.style.display=3D"" parent.SetHasNts(1) } return 1 } function ChkAutoAdv() { if(SldHasTrans()) SlideObj.onfilterchange=3DAutoAdv else AutoAdv() } function AutoAdv() { if(!IsWin("PPTSld") || !gUseSldTimings )return var sld=3DGetCurSld() if( (sld.mAdvDelay>0) && !parent.IsFramesMode() ) setTimeout("parent.GoToNextSld()",sld.mAdvDelay) } function GetObj(id) { if(g_supportsPPTHTML) return document.all(id); else return document.getElementById(id); } function SldHasTrans() { return SlideObj.style.getAttribute("filter")!=3D""= } function GetSldId() { return sId=3Dlocation.href.substring(location.href.la= stIndexOf('/')+1) } function HideMenu() { if( frames["PPTSld"] && PPTSld.document.all.item("ctx= tmenu") && PPTSld.ctxtmenu.style.display!=3D"none" ) { PPTSld.ctxtmenu.styl= e.display=3D'none'; return true } return false } function IsWin( name ) { return window.name =3D=3D name } function IsNts() { return IsWin("PPTNts") } function IsSldOrNts() { return( IsWin("PPTSld")||IsWin("PPTNts") ) } function SupportsPPTAnimation() { return( navigator.platform =3D=3D "Win32"= && navigator.appVersion.indexOf("Windows")>0 ) } function SupportsPPTHTML() { var appVer=3Dnavigator.appVersion, msie=3DappVer.indexOf("MSIE "), ver=3D0 if( msie >=3D 0 ) ver=3DparseFloat( appVer.substring( msie+5, appVer.indexOf(";",msie) ) ) else ver=3DparseInt(appVer) return( ver >=3D 4 && msie >=3D 0 ) } function _RSW() { if( !g_supportsPPTHTML || IsNts() || ( !g_scaleInFrame && (!IsWin("PPTSld") || !parent.IsFullScrMode()) ) ) return var padding=3D0; if( IsWin("PPTSld") && parent.IsFramesMode() ) padding=3D6 cltWidth=3Ddocument.body.clientWidth-padding cltHeight=3Ddocument.body.clientHeight-padding factor=3D(1.0*cltWidth)/g_origW if( cltHeight < g_origH*factor ) factor=3D(1.0*cltHeight)/g_origH newSize =3D g_origSz * factor if( newSize < 1 ) newSize=3D1 s=3DSlideObj.style s.fontSize=3DnewSize+"px" s.posWidth=3Dg_origW*factor s.posHeight=3Dg_origH*factor s.posLeft=3D(cltWidth-s.posWidth+padding)/2 s.posTop=3D(cltHeight-s.posHeight+padding)/2 if( g_scaleHyperlinks ) ScaleHyperlinks( factor ) } function _InitAnimations() { animRuntimeInstalled =3D ''+document.body.localTime !=3D 'undefined'; isFullScreen =3D (window.name =3D=3D "PPTSld") && !parent.IsFramesMode(); g_animUseRuntime =3D g_showAnimation && animRuntimeInstalled && !(isFullSc= reen && parent.IsSldVisited()); if( g_animUseRuntime ) { collSeq =3D document.all.tags("seq"); if( collSeq !=3D null ) { for(ii=3D0;ii numSlds ) gSldJumpIdx =3D numSlds; if ( gSldJumpIdx >=3D 0 ) { if ( gSldJumpIdx =3D=3D 0 ) gSldJumpIdx =3D 1; var jumpTo =3D parseInt(gSldJumpIdx); gSldJump =3D 0; gSldJumpIdx =3D ""; win.GoToSld( parent.GetSldList().mList[jumpTo-1].mSldHref ) } } } function _KDH() { if( event.keyCode =3D=3D 8 ) { event.returnValue =3D 0; parent.GoToPrevSld(); } } function DocumentOnClick() { if( IsNts() || parent.HideMenu() ) return; if( ( g_allowAdvOnClick && !parent.IsFramesMode() ) || (event && (event.keyCode=3D=3D32) ) ) parent.GoToNextSld(); } var g_supportsPPTHTML =3D SupportsPPTHTML(), g_scaleInFrame =3D 1, gId=3D""= , g_bgSound=3D"", g_scaleHyperlinks =3D false, g_allowAdvOnClick =3D 1, g_showInBrowser = =3D 0, gLoopCont =3D 0, gUseSldTimings =3D 0; var g_showAnimation =3D g_supportsPPTHTML && SupportsPPTAnimation() && ( (w= indow.name=3D=3D"PPTSld" && !parent.IsFramesMode()) || g_showInBrowser );va= r g_animManager =3D null; var g_animUseRuntime =3D false; var g_animItemsToHide, g_animInteractiveItems, g_animSlideTime; var g_animMainSequence =3D null; var ENDSHOW_MESG=3D"Fin du diaporama, cliquez pour quitter.", SCREEN_MODE= =3D"Frames", gIsEndShow=3D0, NUM_VIS_SLDS=3D14, SCRIPT_HREF=3D"script.js", = FULLSCR_HREF=3D"fullscreen.htm"; var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO= tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true window.gPPTHTML=3DSupportsPPTHTML() var gMainDoc=3Dnew Array(new hrefList("slide0003.htm",1,6241,1),new hrefLis= t("slide0043.htm",1,5969,1),new hrefList("slide0018.htm",1,5969,1),new href= List("slide0074.htm",1,-1,1),new hrefList("slide0066.htm",1,-1,1),new hrefL= ist("slide0069.htm",1,-1,1),new hrefList("slide0075.htm",1,-1,1),new hrefLi= st("slide0076.htm",1,-1,1),new hrefList("slide0070.htm",1,-1,1),new hrefLis= t("slide0073.htm",1,-1,1),new hrefList("slide0072.htm",1,-1,1),new hrefList= ("slide0067.htm",1,-1,1),new hrefList("slide0068.htm",1,-1,1),new hrefList(= "slide0065.htm",1,-1,1)); function FullScrInit() { g_allowAdvOnClick =3D GetCurSld().mAdvOnClk document.body.style.backgroundColor=3D"black" document.oncontextmenu=3Dparent._CM; document.onkeydown =3D _KDH; document.ondragstart=3DCancel document.onselectstart=3DCancel self.focus() } function Redirect( frmId ) { var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId() if(idx>=3D0) str=3Dstr.substr(1); if( window.name !=3D frmId && ( sId !=3D str) ) { obj =3D GetObj("Main-File") window.location.href=3Dobj.href+"#"+sId return 1 } return 0 } var MHTMLPrefix =3D CalculateMHTMLPrefix(); function CalculateMHTMLPrefix() { if ( document.location.protocol =3D=3D 'mhtml:') { href=3Dnew String(document.location.href) Start=3Dhref.indexOf('!')+1 End=3Dhref.lastIndexOf('/')+1 if (End < Start) return href.substring(0, Start) else return href.substring(0, End) } return ''; } function GetTags(base,tag) { if(g_supportsPPTHTML) return base.all.tags(tag); else return base.getElementsByTagName(tag); } function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP= refix+GetHrefObj( gCurSld ).mNtsHref ) } function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() } function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() } function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() } function SetHasNts( fVal ) { if( gHasNts !=3D fVal ) { gHasNts=3DfVal UpdNavPane() } } function ToggleOtlText() { gOtlTxtExp=3D!gOtlTxtExp UpdOtlPane() } function ToggleOtlPane() { frmset=3Ddocument.all("PPTHorizAdjust") frm=3Ddocument.all("PPTOtl") if( gOtlOpen ) frmset.cols=3D"*,100%" else frmset.cols=3D"25%,*" gOtlOpen=3D!gOtlOpen frm.noResize=3D!frm.noResize UpdOtNavPane() } function ToggleNtsPane() { frmset=3Ddocument.all("PPTVertAdjust") frm=3Ddocument.all("PPTNts") if( gNtsOpen ) frmset.rows=3D"100%,*" else frmset.rows=3D"*,20%" gNtsOpen=3D!gNtsOpen UpdNtsPane() } function ClearMedia() { if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0; } function FullScreen() { if ( PPTSld.g_animUseRuntime ) PPTSld.document.body.pause(); ClearMedia(); var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else return gCurSld } function GetNumSlds() { if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; PPTSld.location.replace(MHTMLPrefix+obj.mSldHref) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 PPTSld.location.replace(MHTMLPrefix+href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document doc.open() doc.writeln('


' + ENDSHOW_MESG + '

') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); function ImgBtn( oId,bId,w,action ) { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } function TxtBtn( oId,oeId,action,chkState ) { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new TxtBtn( "nb_nts","nb_ntsElem",parent.ToggleNtsPan= e,GetNtsState ) gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","nb_prevBorder",30,parent.GoToP= revSld ) gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","nb_nextBorder",30,parent.GoToN= extSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D new ImgBtn( "nb_voice","nb_voiceBorder",18,parent.= ToggleVNarration ) gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlTxt","nb_otlTxtBorder",23,parent= .ToggleOtlText ) gBtnArr["nb_nts"].m_flagId=3D "notes_flag" gBtnArr["nb_nts"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState var sNext=3D"Suivant",sPrev=3D"Précédent",sEnd=3D"Mettre fin = au diaporama",sFont=3D"Arial",sArrow=3D"Flèche",sFreeform=3D"Forme l= ibre",sRect=3D"Rectangle",sOval=3D"Ovale" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( PPTSld.document.body ) mObj.id=3D"ctxtmenu" mObj.style.visibility=3D"hidden" var s=3DmObj.style s.position=3D"absolute" s.cursor=3D"default" s.width=3D"120px" SetCMBorder(mObj,"menu","black") var iObj=3DCreateItem( mObj ) SetCMBorder( iObj, "threedhighlight","threedshadow" ) iObj.style.padding=3D2 CreateMenuItem( iObj,sNext,M_GoNextSld,M_True ) CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld ) CreateSeparator( iObj ) CreateMenuItem( iObj,sEnd,M_End,M_True ) mObj.style.visibility=3D"visible" } function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa= lue=3Dfalse } function Highlight() { ChangeClr("activecaption","threedhighlight") } function Deselect() { ChangeClr("threedface","menutext") } function Perform() { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) e.Action() else PPTSld.event.cancelBubble=3Dtrue } function ChangeClr( bg,clr ) { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) { e.style.backgroundColor=3Dbg e.style.color=3Dclr } } function M_HasPrevSld() { return( parent.HasPrevSld() ) } function M_GoNextSld() { if( gIsEndShow ) M_End(); 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Diaporama=
Plan
<= /a>= = = = =
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