Français Anglais
Accueil Annuaire Plan du site
Home > Research results > Research highlights
Research results
Research highlight : A STOCHASTIC AUTOMATON SHOWS HOW ENZYME ASSEMBLIES MAY CONTRIBUTE TO METABOLIC EFFICIENCY
A STOCHASTIC AUTOMATON SHOWS HOW ENZYME ASSEMBLIES MAY CONTRIBUTE TO METABOLIC EFFICIENCY
25 March 2008

By Patrick Amar et Al.
BMC Systems Biology 2008, 2:27
The advantages of grouping enzymes into metabolons and into higher order structures have long been debated. To quantify these advantages, we have developed a stochastic automaton that allows experiments to be performed in a virtual bacterium with both a membrane and a cytoplasm. We have investigated the general case of transport and metabolism as inspired by the phosphoenolpyruvate:sugar phosphotransferase system (PTS) for glucose importation and by glycolysis.

We show that PTS and glycolytic metabolons can increase production of pyruvate eightfold at low concentrations of phosphoenolpyruvate. A fourfold increase in the numbers of enzyme EI led to a 40% increase in pyruvate production, similar to that observed in vivo in the presence of glucose. Although little improvement resulted from the assembly of metabolons into a hyperstructure, such assembly can generate gradients of metabolites and signaling molecules.

Patrick Amar, G. Legent, M. Thellier, C. Ripoll, G. Bernot, T. Nystrom, M. Saier Jr and Vic Norris



Keyword
  ° Design
  ° Bioinformatics

Group
  ° Bioinformatics

Contact
  ° AMAR Patrick
Research highlights
INFORMATION-GEOMETRIC OPTIMIZATION ALGORITHMS: A UNIFYING PICTURE VIA INVARIANCE PRINCIPLES
2 May 2017
Yann Ollivier, Ludovic Arnold, Anne Auger, Nikolaus Hansen - JMLR 18(18):1−65, 2017.

FORMAL MUTATION TESTING FOR CIRCUS
21 April 2016
Alex Donizeti Betez Alberto, Ana Cavalcanti, Marie-Claude Gaudel, Adenilso Simao Journal of Infor

CELL-CELL COMMUNICATION ENHANCES THE CAPACITY OF CELL ENSEMBLES TO SENSE SHALLOW GRADIENTS DURING MORPHOGENESIS
9 February 2016
D. Ellison, A. Mugler, M.D. Brennan, S.H. Lee, R.J. Huebner, E.R. Shamir, L.A. Woo, J. Kim, P. Amar

COMPUTING WITH SYNTHETIC PROTOCELLS
13 May 2015
Alexis Courbet, Franck Molina and Patrick Amar

ICDE 2015 TUTORIAL: RDF DATA MANAGEMENT: REASONING ON WEB DATA
27 October 2014