Français Anglais
Accueil Annuaire Plan du site
Home > Research results > Research highlights
Research results
Research highlight : A STOCHASTIC AUTOMATON SHOWS HOW ENZYME ASSEMBLIES MAY CONTRIBUTE TO METABOLIC EFFICIENCY
A STOCHASTIC AUTOMATON SHOWS HOW ENZYME ASSEMBLIES MAY CONTRIBUTE TO METABOLIC EFFICIENCY
25 March 2008

By Patrick Amar et Al.
BMC Systems Biology 2008, 2:27
The advantages of grouping enzymes into metabolons and into higher order structures have long been debated. To quantify these advantages, we have developed a stochastic automaton that allows experiments to be performed in a virtual bacterium with both a membrane and a cytoplasm. We have investigated the general case of transport and metabolism as inspired by the phosphoenolpyruvate:sugar phosphotransferase system (PTS) for glucose importation and by glycolysis.

We show that PTS and glycolytic metabolons can increase production of pyruvate eightfold at low concentrations of phosphoenolpyruvate. A fourfold increase in the numbers of enzyme EI led to a 40% increase in pyruvate production, similar to that observed in vivo in the presence of glucose. Although little improvement resulted from the assembly of metabolons into a hyperstructure, such assembly can generate gradients of metabolites and signaling molecules.

Patrick Amar, G. Legent, M. Thellier, C. Ripoll, G. Bernot, T. Nystrom, M. Saier Jr and Vic Norris



Keyword
  ° Design
  ° Bioinformatics

Group
  ° Bioinformatics

Contact
  ° AMAR Patrick
Research highlights
COMPUTER‐AIDED BIOCHEMICAL PROGRAMMING OF SYNTHETIC MICROREACTORS AS DIAGNOSTIC DEVICES
27 April 2018
Alexis Courbet, Patrick Amar, Francois Fages, Eric Renard, Franck Molina Mol Syst Biol. (2018) 14:

SELF-STABILIZING DISTRIBUTED STABLE MARRIAGE
5 November 2017


A MODEL OF PULSATION FOR EVOLUTIVE FORMALIZING INCOMPLETE INTELLIGENT SYSTEMS
27 July 2017


INFORMATION-GEOMETRIC OPTIMIZATION ALGORITHMS: A UNIFYING PICTURE VIA INVARIANCE PRINCIPLES
2 May 2017
Yann Ollivier, Ludovic Arnold, Anne Auger, Nikolaus Hansen - JMLR 18(18):1−65, 2017.

FORMAL MUTATION TESTING FOR CIRCUS
21 April 2016
Alex Donizeti Betez Alberto, Ana Cavalcanti, Marie-Claude Gaudel, Adenilso Simao Journal of Infor