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Research highlight : GENOME-WIDE HAPLOTYPE ASSOCIATION STUDY IDENTIFIES THE SLC22A3-LPAL2-LPA GENE CLUSTER AS A RISK LOCUS FOR CORONARY ARTERY DISEASE
GENOME-WIDE HAPLOTYPE ASSOCIATION STUDY IDENTIFIES THE SLC22A3-LPAL2-LPA GENE CLUSTER AS A RISK LOCUS FOR CORONARY ARTERY DISEASE
26 March 2009

Brief Communication abstract:
David-Alexandre Trégouët, Inke R König, Jeanette Erdmann, Alexandru Munteanu, Peter S Braund, Alistair S Hall, Anika Gros zlighennig, Patrick Linsel-Nitschke, Claire Perret, Maylis DeSuremain, Thomas Meitinger, Ben J Wright, Michael Preuss, Anthony J Balmforth, Stephen G Ball, Christa Meisinger, Cécile Germain, Alun Evans, Dominique Arveiler, Gérald Luc, Jean-Bernard Ruidavets, Caroline Morrison, Pim van der Harst, Stefan Schreiber, Katharina Neureuther, Arne Schäfer, Peter Bugert, Nour E El Mokhtari, Jürgen Schrezenmeir, Klaus Stark, Diana Rubin, H-Erich Wichmann, Christian Hengstenberg, Willem Ouwehand, Wellcome Trust Case Control Consortium, Cardiogenics Consortium, Andreas Ziegler, Laurence Tiret, John R Thompson, Francois Cambien, Heribert Schunkert & Nilesh J Samani

We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

Nature Genetics 41, 283 - 285 (2009)
Published online: 8 February 2009 | doi:10.1038/ng.314



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