Français Anglais
Accueil Annuaire Plan du site
Accueil > Evenements > Séminaires
Séminaire d'équipe(s) BioInfo
Modeling RNA by hierarchical natural moves
Adelene Sim

18 October 2012, 15h00 - 18 October 2012, 16h00
Salle/Bat : 465/PCRI-N
Contact :

Activités de recherche :

Résumé :
Structured RNA usually folds hierarchically, with its sequence defining stable secondary structure that constrains how the RNA then folds in three dimensions.
RNA secondary structure defines helix-junction-helix motifs that are the essential building blocks of RNA. We recently developed a computational sampling algorithm that allows us to extensively explore the conformational space of RNA by embedding different levels of the degrees of freedom used for sampling. For example, helices can move independently and in correlation with one or more other helices.
Additionally, these helices are not perfectly rigid: bases within helices are free to move. The combination of hierarchical degrees of freedom facilitates the exploration of physically relevant RNA structures sampled using any potential energy function.
We benchmarked and compared our algorithm to others using simple and symmetric RNA systems.
We also modeled the effects of sequence mutations on the structural building blocks of tRNA-based nanotechnology. Future applications will also be discussed.

Pour en savoir plus :
Séminaires
Some recent results on the integer linear programm
Théorie des graphes
Friday 30 November 2018 - 00h00
Salle : 445 - PCRI-N
Hung Nguyen .............................................

Maximum Independent Set in H-free graphs
Théorie des graphes
Friday 05 October 2018 - 14h30
Salle : 445 - PCRI-N
Edouard BONNET .............................................

A Family of Tractable Graph Distances
Gestion de données du Web
Wednesday 04 July 2018 - 10h30
Salle : 465 - PCRI-N
Stratis Ioannidis .............................................

Binary pattern of length greater than 14 are abeli
Combinatoire
Friday 29 June 2018 - 14h30
Salle : 445 - PCRI-N
Matthieu Rosenfeld .............................................

Distributionally Robust Optimization with Principa
Optimisation combinatoire et stochastique
Friday 29 June 2018 - 11h00
Salle : 455 - PCRI-N
Dr. Jianqiang Cheng .............................................