Français Anglais
Accueil Annuaire Plan du site
Accueil > Evenements > Séminaires
Séminaire d'équipe(s) BioInfo
Formal Modeling, Data Integration and Quantitative Verification of large-scale cell-based models.
Louis Fippo Fitime

08 October 2015, 00h00
Salle/Bat : 475/PCRI-N
Contact :

Activités de recherche : Biologie des systèmes

Résumé :
In this work we propose an automatic way of generating and verifying formal hybrid models of signaling and transcriptional events, gathered in large-scale regulatory networks.This is done by integrating temporal and stochastic aspects of the expression of some biological components. The hybrid approach lies in the fact that measurements take into account both times of lengthening phases and discrete switches between them. The model proposed is based on a real case study of keratinocytes differentiation, in which gene time-series data was generated upon Calcium stimulation.

To achieve this we rely on the Process Hitting (PH) formalism that was designed to consider large-scale system analysis. We first propose an automatic way of detecting and translating biological motifs from the Pathway Interaction Database to the PH formalism. Then, we propose a way of estimating temporal and stochastic parameters from time-series expression data of action on the PH. Simulations emphasize the interest of synchronizing concurrent events.

Pour en savoir plus :
Séminaires
Programming computing media (reporté)
Combinatoire
Friday 18 September 2020 - 14h30
Salle : 445 - PCRI-N
Frédéric Gruau .............................................

forum-dev Continuous Integration
Friday 05 June 2020 - 10h00
Salle : 0 - 650
Erik Bray .............................................

Large-scale Spectral Clustering for GPU-based Plat
Calcul à haute performance
Tuesday 24 March 2020 - 10h30
Salle : 465 - PCRI-N
Guanlin He .............................................

Recherche Opérationnelle à Google
Optimisation combinatoire et stochastique
Thursday 12 March 2020 - 14h30
Salle : 445 - PCRI-N
Laurent Perron .............................................

Forum dev-LRI
Wednesday 05 February 2020 - 14h00
Salle : 455 - PCRI-N
Erik Bray .............................................