Français Anglais
Accueil Annuaire Plan du site
Accueil > Evenements > Séminaires
Protein coevolution and the viral world
Alessandra Carbone

26 January 2017, 14h30
Salle/Bat : 465/PCRI-N
Contact :

Activités de recherche : Biologie structurale

Résumé :
A fundamental question in computational biology is the extraction of evolutionary information from DNA sequences. Here, we consider protein sequences and structures, and describe how important biological information on protein-protein binding sites and on mechanical and allosteric properties of proteins can be extracted. Among different examples, we shall present a computational approach to protein-protein interactions that we developed within a project on protein network reconstruction for viral genomes. We show how the full interaction network of proteins coded in Hepatitis C Virus genome can be reconstructed at a residue/domain resolution and briefly introduce recent experimental work demonstrating HCV fusion as a unique mechanism. This work provides a proof of concept for a wider exploration of viral protein mediated-processes and highlights coevolution as a valuable tool for guiding the design of viral inhibitors.

Pour en savoir plus :
Séminaires
A Two-level Auction for Resource Allocation in Mul
Réseaux sans fil et mobiles
Friday 09 March 2018 - 14h30
Salle : 445 - PCRI-N
Mira Morcos .............................................

Binary pattern of length greater than 14 are abeli
Combinatoire
Friday 09 February 2018 - 14h30
Salle : 445 - PCRI-N
Matthieu Rosenfeld .............................................

Approximate Bayesian Computation and Random Forest
Thursday 08 February 2018 - 00h00
Salle : 455 - PCRI-N
Valentin Thouzeau .............................................

A concurrent lock-free algorithm for computing a f
Combinatoire
Friday 12 January 2018 - 14h30
Salle : 445 - PCRI-N
James Mitchell .............................................

Acyclic Partitioning of Large Directed Acyclic Gra
Calcul à haute performance
Tuesday 09 January 2018 - 10h30
Salle : 465 - PCRI-N
Julien Herrmann .............................................