Français Anglais
Accueil Annuaire Plan du site
Accueil > Evenements > Séminaires
Protein coevolution and the viral world
Alessandra Carbone

26 January 2017, 14h30
Salle/Bat : 465/PCRI-N
Contact :

Activités de recherche : Biologie structurale

Résumé :
A fundamental question in computational biology is the extraction of evolutionary information from DNA sequences. Here, we consider protein sequences and structures, and describe how important biological information on protein-protein binding sites and on mechanical and allosteric properties of proteins can be extracted. Among different examples, we shall present a computational approach to protein-protein interactions that we developed within a project on protein network reconstruction for viral genomes. We show how the full interaction network of proteins coded in Hepatitis C Virus genome can be reconstructed at a residue/domain resolution and briefly introduce recent experimental work demonstrating HCV fusion as a unique mechanism. This work provides a proof of concept for a wider exploration of viral protein mediated-processes and highlights coevolution as a valuable tool for guiding the design of viral inhibitors.

Pour en savoir plus :
Séminaires
A Family of Tractable Graph Distances
Gestion de données du Web
Wednesday 04 July 2018 - 10h30
Salle : 465 - PCRI-N
Stratis Ioannidis .............................................

Binary pattern of length greater than 14 are abeli
Combinatoire
Friday 29 June 2018 - 14h30
Salle : 445 - PCRI-N
Matthieu Rosenfeld .............................................

Distributionally Robust Optimization with Principa
Optimisation combinatoire et stochastique
Friday 29 June 2018 - 11h00
Salle : 455 - PCRI-N
Dr. Jianqiang Cheng .............................................

Caractérisation de réseaux égocentrés par l'énumér
Friday 15 June 2018 - 14h30
Salle : 455 - PCRI-N
Raphaël Charbey .............................................

DATA VERACITY ASSESSMENT: HOW A-PRIORI KNOWLEDGE E
Intégration de données et de connaissances
Friday 15 June 2018 - 14h00
Salle : 445 - PCRI-N
Valentina Beretta .............................................