Français Anglais
Accueil Annuaire Plan du site
Accueil > Evenements > Séminaires
Direct-Coupling Analysis of nucleotide coevolution facilitates RNA secondary and tertiary structure prediction
Martin Weigt

18 May 2017, 16h00
Salle/Bat : 465/PCRI-N
Contact :

Activités de recherche :

Résumé :
Despite the biological importance of non-coding RNA, their structural characterization remains challenging. Making use of the rapidly growing sequence databases, we analyze nucleotide coevolution across homologous sequences via Direct-Coupling Analysis (DCA) to detect nucleotide-nucleotide contacts. DCA is a global statistical modeling approach, which has been originally developed for predicting residue-residue contacts in proteins, and which has been used successfully for guiding tertiary and quaternary protein structure prediction.

In the case of RNA, the use of coevolutionary information has been restricted to secondary structure prediction. For a representative set of riboswitches, we show that the results of DCA in combination with a generalized Nussinov algorithm systematically improve the results of RNA secondary structure prediction beyond the traditional covariance approaches based on mutual information. Even more importantly, we show that the results of DCA are enriched in tertiary structure contacts. By integrating these predictions into molecular modeling tools, systematically improved tertiary structure predictions can be obtained, as compared to using secondary structure information alone.

Pour en savoir plus :
Séminaires
Programming computing media (reporté)
Combinatoire
Friday 18 September 2020 - 14h30
Salle : 445 - PCRI-N
Frédéric Gruau .............................................

forum-dev Continuous Integration
Friday 05 June 2020 - 10h00
Salle : 0 - 650
Erik Bray .............................................

Large-scale Spectral Clustering for GPU-based Plat
Calcul à haute performance
Tuesday 24 March 2020 - 10h30
Salle : 465 - PCRI-N
Guanlin He .............................................

Recherche Opérationnelle à Google
Optimisation combinatoire et stochastique
Thursday 12 March 2020 - 14h30
Salle : 445 - PCRI-N
Laurent Perron .............................................

Forum dev-LRI
Wednesday 05 February 2020 - 14h00
Salle : 455 - PCRI-N
Erik Bray .............................................