Français Anglais
Accueil Annuaire Plan du site
Accueil > Evenements > Séminaires
Salle 465 - Direct-Coupling Analysis of nucleotide coevolution facilitates RNA secondary and tertiary structure prediction
Martin Weigt

18 May 2017, 16h00
Salle/Bat : 465/PCRI-N
Contact :

Activités de recherche :

Résumé :
Despite the biological importance of non-coding RNA, their structural characterization remains challenging. Making use of the rapidly growing sequence databases, we analyze nucleotide coevolution across homologous sequences via Direct-Coupling Analysis (DCA) to detect nucleotide-nucleotide contacts. DCA is a global statistical modeling approach, which has been originally developed for predicting residue-residue contacts in proteins, and which has been used successfully for guiding tertiary and quaternary protein structure prediction.

In the case of RNA, the use of coevolutionary information has been restricted to secondary structure prediction. For a representative set of riboswitches, we show that the results of DCA in combination with a generalized Nussinov algorithm systematically improve the results of RNA secondary structure prediction beyond the traditional covariance approaches based on mutual information. Even more importantly, we show that the results of DCA are enriched in tertiary structure contacts. By integrating these predictions into molecular modeling tools, systematically improved tertiary structure predictions can be obtained, as compared to using secondary structure information alone.

Pour en savoir plus :
Séminaires
A Family of Tractable Graph Distances
Gestion de données du Web
Wednesday 04 July 2018 - 10h30
Salle : 465 - PCRI-N
Stratis Ioannidis .............................................

Binary pattern of length greater than 14 are abeli
Combinatoire
Friday 29 June 2018 - 14h30
Salle : 445 - PCRI-N
Matthieu Rosenfeld .............................................

Distributionally Robust Optimization with Principa
Optimisation combinatoire et stochastique
Friday 29 June 2018 - 11h00
Salle : 455 - PCRI-N
Dr. Jianqiang Cheng .............................................

Caractérisation de réseaux égocentrés par l'énumér
Friday 15 June 2018 - 14h30
Salle : 455 - PCRI-N
Raphaël Charbey .............................................

DATA VERACITY ASSESSMENT: HOW A-PRIORI KNOWLEDGE E
Intégration de données et de connaissances
Friday 15 June 2018 - 14h00
Salle : 445 - PCRI-N
Valentina Beretta .............................................