Français Anglais
Accueil Annuaire Plan du site
Accueil > Evenements > Séminaires
Séminaire d'équipe(s) BioInfo
Predicting the structure of RNA-binding protein recognition elements
François Major

23 May 2019, 00h00
Salle/Bat : 465/PCRI-N
Contact :

Activités de recherche :

Résumé :
Improvements in genomics give us access to an unprecedented amount of RNA sequence data, coding and non-coding. It is a general desire to determine the structure and function of these RNAs in order to discover: binding sites to proteins, DNA, other RNAs, and small molecules; search in transcriptomic and genomic data for sequences with similar structure and function; and, design new sequences with predetermined properties. The success of accomplishing these tasks depends on the representation of an RNA sequence that we use. Here, I will introduce a new representation based on a feature vector that is appropriate to machine learning, which we are using to identify overrepresented structural motifs from RNA folding prediction data. Interestingly, the overrepresented motifs are determinants of RNA function. From this representation, we derive decision-tree based RNA family classifiers, and show that mutations that affect the outcome of these trees also affect function. Finally, we use it to model and search for the structure of RNA-binding protein recognition elements.

Pour en savoir plus :
Séminaires
La transformation du travail, un analyseur des tra
Wednesday 18 December 2019 - 10h00
Salle : 475 - PCRI-N
Raquel Becerril-Ortega .............................................

Scalable Load Balancing with Distributed Algorithm
Calcul à haute performance
Tuesday 17 December 2019 - 10h30
Salle : 465 - PCRI-N
Vinicius Freitas .............................................

L-orientations of graphs
Théorie des graphes
Friday 06 December 2019 - 14h30
Salle : 475 - PCRI-N
Kenta Ozeki .............................................

Forum dev-LRI
Tuesday 26 November 2019 - 14h00
Salle : 445 - PCRI-N
Jonas et Erik .............................................

Optimal curing policy for epidemic spreading over
Réseaux
Friday 22 November 2019 - 14h30
Salle : 445 - PCRI-N
Francesco De Pellegrini .............................................