Français Anglais
Accueil Annuaire Plan du site
Accueil > Evenements > Séminaires
Séminaire d'équipe(s) Bioinformatics
Protein-protein interactions: co-evolution, prediction and design
Jessica Andreani-Feuillet

18 October 2012, 14:00 - 18 October 2012, 15:00
Salle/Bat : 465/PCRI-N
Contact :

Activités de recherche :

Résumé :
In order to analyze protein-protein interactions, we focus on the combined use of structural data and evolutionary information.
In a study of over 1,000 couples of homologous heteromeric interfaces, we uncover astonishing plasticity in the way interface structure evolves, although we identify some rather invariant features which provide tracks for extracting meaningful information from multiple sequence alignments of binding partners.
Consequently, we develop a knowledge-based potential relying on evolutionary interface descriptors to improve the prediction of protein interfaces.
Finally, a better understanding of protein-protein interactions has major implications with regard to the design of specific interaction inhibitors.

Pour en savoir plus :
Séminaires
Pierre Andrieu - Agrégation de classements pour le
Thursday 21 October 2021 - 00:00
Salle : 435 - PCRI-N
.............................................

A counting argument for graph colouring
Graph Theory
Friday 08 October 2021 - 11:00
Salle : 445 - PCRI-N
Francois Pirot .............................................

Demographic reconstruction from paleogenomes of th
Thursday 25 February 2021 - 14:00
Salle : 435 - PCRI-N
Nina Marchi .............................................

A Graph-based Similarity Approach to Classify Recu
Thursday 18 February 2021 - 14:00
Salle : 435 - PCRI-N
Coline Gianfrotta .............................................

"Answer Set Programming for computing constraints-
Thursday 04 February 2021 - 14:00
Salle : 435 - PCRI-N
Maxime Mahout .............................................