Data analyses in functional genomics: two different stories based on deep sequencing technologies in micro-organisms
23 March 2017, 14:30
Salle/Bat : /
Activités de recherche :
I am a new Professor at the University Paris Sud (since September 2016). I joined the I2BC institute, in the research team of Olivier Lespinet. My research interests are related to the analyses of experimental datasets in functional genomic projects. During this seminar, I will present original results we obtained in two different studies, based on deep sequencing technologies. In the first project (reference 1), we combined genome-wide chromatin immunoprecipitation (ChIP-seq), transcriptome analyses, and DNA binding motif predictions to characterize the regulatory interactions of the seven Yap (Yeast AP1) transcription factors of the pathogenic yeast Candida glabrata. In the second project (reference 2), we used RNA sequencing to investigate the transcriptional responses to iron limitation in the microalgae Ostreococcus tauri. I will conclude with ongoing research projects and open discussions.
Pour en savoir plus : http://gaelle.lelandais.info/
(1) A network of paralogous stress response transcription factors in the human pathogen Candida glabrata. J. Merhej, A. Thiebaut, C. Blugeon, J. Pouch, A. Ali Chaouche Mel, JM. Camadro, S. Le Crom, G. Lelandais*, F. Devaux*. Front Microbiol. 2016 May 9;7:645. doi: 10.3389/fmicb.2016.00645. eCollection 2016
(2) Ostreococcus tauri is a new model green alga for studying iron metabolism in eukaryotic phytoplankton. G. Lelandais*; I. Scheiber*; J. Paz-Yepes; J.C Lozano; H. Botebol; J. Pilátová; V. Žárský; T. Léger; P.L Blaiseau; C. Bowler; F.Y Bouget; J.M Camadro; R. Sutak; E. Lesuisse. BMC Genomics. 2016 May 3;17(1):319. doi: 10.1186/s12864-016-2666-6.