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Séminaire d'équipe(s) Bioinformatics
Disentangling the role of selection on the evolution of genomes.
Fanny Pouyet

02 October 2020, 17:30
Salle/Bat : 455/PCRI-N
Contact :

Activités de recherche :

Résumé :
Abstract:
Genomic diversity evolves under evolutionary factors such as mutations,
selection, gene flow and demography. Across a genome, genomic diversity
varies with recombination in complex ways that we will present. In this
talk we offer to better understand the role of recombination on
diversity at a genome-wide scale. This will help us to properly
reconstruct the demographic history of species.

We will start using the high-quality human genomic data to show that
linkage to sites under selection and a second mechanism determined by
base composition affect as much as 95% of the variants of our genome.
Interestingly, synonymous sites and non-transcribed regions are also
affected, albeit to different degrees such that their use for
demographic inference can lead to strong biases that we will illustrate
by reconstructing the history of 2 populations.
Second, we will discuss other intricate links between recombination and
evolutionary processes across the genome in regions of very low
recombination. Specifically, we will discuss the effect of associative
over-dominance which can lead to an increase of diversity even in the
absence of recombination.
We will then spend a few slides to describe my research project.
Especially we will motivate the shift of model organism (from human to
yeast) that will help us tackle with more precision the role of
selection on the evolution of genomes.

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